Born in Greece, George Metakides received his PhD in Mathematical Logic from Cornell University, United States, in 1971. He pursued an academic career at MIT, Cornell and Rochester University until 1978, when he returned to Greece after being elected to the Chair of Logic at the University of Patras.

Since 1984, he has held senior positions with responsibility for R&D policy, funding and international cooperation in European institutions. He established and headed the Department for Basic Research and International Scientific Relations in Information Technologies at the European Commission from 1988 to 1993. He was Director of the European Strategic Programme for Information Technologies (ESPRIT), from 1993 until its completion in 1998, followed by the Information Society Technologies Programme (IST, 1998-2002).

George is currently Professor at the University of Patras, President of the Scientific Board of the Hellenic Computer Technology Institute and Advisor to several international organisations. He is active in the promotion of cooperation between the European Union and other regions and has contributed to the establishment of research agreements between the EU and the United States, including the launch of the World Wide Web Consortium. He is involved in a number of joint actions in the Balkan and Mediterranean regions. As a co-founder of Dgital Enlightenment Forum he serves as president since its start.